The family started in the 1920s in Chicago and were responsible for racketeering, illegal gambling, prostitution, arms trafficking, murder, fencing, extortion, assault, smuggling, bribery, and narcotics. Boss Patrick O'Donnell was a sly boss, working under the thumb of the Chicago Outfit; the O'Donnells tried to move to New York City under Chicago's eye. However, Patrick was thrown off a building by rival Corleone crime family gangster Aldo Trapani, who wanted to protect Corleone interests from the Irish Mob. Shortly after, the O'Donnells went to war with the Stracci crime family. Ray and James Scaleri were assassinated by Trapani, taking advantage of the war. With their members dead, the family was defunct.